More wacky shenanigans abound as world's most pessimistic guy, Nozomu Itoshiki (a.k.a. Zetsubou-sensei), tries to educate class 2-F about how life is full of misery and darkness. A more difficult task than it appears at first, given that his students are anything but ordinary, including the most positive girl he's ever met, his very own stalker, a foreign exchange student with split personalities, and a perfectionist acting class president, due to the fact that the real class president can't be seen, among others.