Masane Amaha and her daughter Rihoko are fleeing a government child care agency that seeks to separate Rihoko from her mother. They are apprehended, and Rihoko is taken away. Meanwhile, Masane is assaulted by an advanced weapon that can impersonate a human. When she is confronted with a threat, a weird light emanates from her wrist, and she changes into a strong entity. She destroys the weapon, becoming embroiled in a power war between powerful groups, with her at the center of their attention. Because she has the most powerful power of all, the fabled Witchblade.