Nobody could have imagined the impact of World War III on Japan at the outset. While it officially ended fifty years ago in 2150, the fights continue. Across the land, large, strange places known as "Blackspots" developed, filled with tainted remnants of towns and countrysides. Those locked within were trapped to stop the spread of contamination, and their powers began to mutate—whether shapeshifters, pyromancers, or gravity controllers, they all became known as the Needless. Adam Blade is one such Needless, possessing remarkable regenerative abilities and incredible strength. To bring peace to a war-torn Japan, he and his friends must band together to confront a terrible research group known as Simeon.