Man perceived the malformed ones as weird and dreaded them throughout time, and they were known as Mushi. Although they have no ill will toward humans, many suffer as a result of their presence and peculiar nature; using the Mushi without knowing them, even accidentally, can lead to tragedy and struggle for all parties involved. Mushishi Zoku Shou continues Mushishi Ginko's effort to assist the visible world in coexisting with the Mushi. Ginko discovers numerous gifted individuals—those plagued by fate and those preserving a precarious relationship with the Mushi—during his travels, inevitably addressing the question of whether mankind, gifted and suffering alike, can manage the duty of the unseen. Furthermore, as a Mushishi, Ginko must understand more about these odd creatures.