Risa Koizumi and Atsushi Ootani, both in high school, are looking for their perfect partner—172 cm tall Koizumi is significantly taller than the ordinary female, while Ootani is much shorter than the normal boy at 156 cm. To make matters worse, their crushes fall in love with each other, leaving Koizumi and Ootani amused and devastated. To make matters worse, their homeroom instructor refers to them as a comic team because of their personalities and the dramatic disparity in their heights, and their pupils regard their disagreements as skits. LovelyComplex follows Koizumi and Ootani as they support each other in their search for love and become close friends. Aside from their crazy antics, they eventually discover unexpected similarity in their music and fashion tastes. Maybe they possess a chemistry yet unknown, but could love ever bloom between the mismatched pair?