After the Little Busters lose their first baseball game, the squad decides to have a pancake feast. It's been over a semester since Kyousuke Natsume returned. Riki Naoe, as usual, continues to assist the Little Busters' members, both old and new, in addressing their inner demons. Strange occurrences, however, continue to occur, bringing Rin Natsume and Riki closer to discovering the truth behind the "secret of this planet." Rin and Rikki had no idea that their finding will forever change the tranquil everyday lives built by the Little Busters. Little Destroyers! Refrain draws to a close the colorful stories of its ensemble cast, which have been created with the weight of emotions and fortified by the tie of friendship, as they come to an end.