Shuuichi Nitori, an effeminate fifth-grader, is widely regarded as one of the most beautiful ladies in school, but, much to her chagrin, she is biologically male. Fortunately, Shuuichi has a childhood buddy who shares his ideas about gender identity: the lanky tomboy Yoshino Takatsuki, who, although being born female, does not identify as a girl. These two friends share a similar secret and find comfort in one another; yet, their lives become much more difficult as they must navigate the unknown waters of a new school, try to establish new friends, and battle to keep existing ones. They must learn to deal with the hard realities of growing up, transexuality, relationships, and acceptance despite virtually insurmountable difficulties.