Young ladies Hakumei and Mikochi dwell together in a home constructed into a tree in a planet populated by humans barely a few inches tall. Hakumei is a boisterous and tomboyish carpenter, whereas Mikochi is a feminine and serene tailor. Despite their differences, they get along well and enjoy spending their days in the woods. They spend their time working, going on tourist expeditions, and shopping at Tsumiki Marketplace near the seaside. Along the way, they make many friends, whether they are sentient forest animals like Iwashi the Weasel or other small people like the soprano Konju and the inventor Sen. Hakumei to Mikochi is a lighthearted look at the daily life of its namesake characters.