Mikan Sakura is your typical ten-year-old girl. Mikan, the optimistic, cheerful, and overall extremely nice youngster, is the polar opposite of Hotaru Imai, the aloof, clever, and sometimes cold-hearted child. Despite their obvious differences, the two girls have been great friends for many years. So when Hotaru is abruptly transferred to Alice Academy, a famous school in the city, her closest friend is upset, especially after hearing dreadful reports about the academy's brutal treatment of pupils. Mikan, overcome with worry, flees to meet her dearest buddy! Mikan discovers the existence of "Alices," people endowed with diverse supernatural talents, and that the school was constructed by the government to teach and protect them. Recognizing that she has a distinct unique powers, Mikan enrolls in the academy, and, after a lot of trouble, finally reunites with Hotaru.